Lamivudine/dolutegravir dual therapy in HIV-infected, virologically suppressed patients
نویسندگان
چکیده
منابع مشابه
Lamivudine/dolutegravir dual therapy in HIV-infected, virologically suppressed patients
BACKGROUND Little is known about the applicability of dual treatments based on integrase inhibitors. We explored the combination of lamivudine + dolutegravir as an option when switching from standard cART in virologically suppressed patients. METHODS In this prospective cohort we enrolled patients previously switched to 3TC + DTG who were 18 years or older, with no previous resistance mutatio...
متن کاملModifying Antiretroviral Therapy in Virologically Suppressed HIV-1-Infected Patients.
HIV-1-infected patients with suppressed plasma viral loads often require changes to their antiretroviral (ARV) therapy to manage drug toxicity and intolerance, to improve adherence, and to avoid drug interactions. In patients who have never experienced virologic failure while receiving ARV therapy and who have no evidence of drug resistance, switching to any of the acceptable US Department of H...
متن کاملDual raltegravir/etravirine combination in virologically suppressed HIV-1-infected patients on antiretroviral therapy.
BACKGROUND The combination of raltegravir (RAL) and etravirine (ETR) represents a novel antiretroviral treatment option in patients with toxicity or long-term exposure to standard therapies including protease inhibitors (PI) and nucleoside reverse transcriptase inhibitors (NRTI). The objective of this study was to evaluate the capacity of dual RAL/ETR therapy to maintain virological suppression...
متن کاملDual therapy with etravirine plus raltegravir for virologically suppressed HIV-infected patients: a pilot study.
BACKGROUND Clinical use of protease inhibitors (PIs) and nucleoside reverse transcriptase inhibitors (NRTIs) may be hampered by toxicity, interactions or resistance issues. Simple and effective antiretroviral regimens avoiding both drug classes may be needed for selected patients. METHODS This was a prospective cohort study. Virologically suppressed patients on PI or NRTI regimens, with probl...
متن کاملRaltegravir and unboosted atazanavir dual therapy in virologically suppressed antiretroviral treatment-experienced HIV patients.
BACKGROUND Because of the favourable safety and tolerability profiles of atazanavir (ATV) and raltegravir (RAL), attention has recently turned to the use of dual ATV plus RAL therapy as a nucleoside reverse transcriptase inhibitor-sparing treatment strategy in highly antiretroviral treatment (ART)-experienced HIV-infected patients. METHODS A retrospective observational study was carried out t...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2017
ISSN: 1471-2334
DOI: 10.1186/s12879-017-2311-2